ImmunologybioRxivPreprint
Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells
L. Ma, D. M. Morgan, I. Sulkaj…·D. J. Irvine
This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.
DOI 10.1101/2022.10.05.511036