J. C. Love

This study identifies spleen-resident intermediate-exhausted T cells as key to ICB efficacy, showing their expansion and differentiation into tumor-infiltrating clonotypes.

The paper develops a method to recover full-length BCR sequences from single-cell RNA libraries and applies it to study convergent B cell responses to vaccination in rhesus macaques.

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.

The paper improves recombinant protein secretion quality and titer in Komagataella phaffii by modifying the N-terminus to enhance steric accessibility of the signal peptide.

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

WAT3R recovers T-cell receptor variable regions from 3' scRNA-seq data, enabling T-cell clonotype reconstruction and analysis of TCR sequences in single cells.

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

The paper introduces a modular media design approach for rapid optimization of cell growth and protein production in Pichia pastoris using high-throughput fermentations and an open-source automation tool.

This paper describes an engineered Komagataella phaffii strain for methanol-free production of SARS-CoV-2 RBD, achieving a 5x increase in secreted titer and enabling scalable manufacturing for vaccine development.

The paper engineers subunit antigens to improve vaccine manufacturing by reducing variants and enabling single-process production of a trivalent rotavirus vaccine.

The paper uses single-cell RNA-sequencing to study leukocyte dynamics in a living patient after intracerebral hemorrhage, revealing rapid immune responses and adaptations to the hematoma microenvironment.

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.