Cell BiologyNature CommunicationsPeer-reviewed
OPA1 protects intervertebral disc and knee joint health in aged mice by maintaining the structure and metabolic functions of mitochondria
Vedavathi Madhu, Miriam Hernandez-Meadows, Ashley Coleman…·Makarand V. Risbud
This study shows that OPA1 maintains mitochondrial structure and metabolic functions in NP cells and chondrocytes, preventing age-related degeneration in mouse intervertebral discs and knee joints.