Pilong Li

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

The paper introduces Phase-APEX2, a method to specifically label membrane-less organelles, revealing their core components and molecular mechanisms.

This study compares temporal transcriptomic changes in iPSC-derived motor neurons with SOD1 mutations D91A and G94A to understand their impact on ALS severity.

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

This study identifies a small molecule that rescues NPM1c phase separation loss, restoring nucleolar localization and showing anti-leukemia activity in AML models.

The paper investigates how amino acid composition affects biomolecular condensate miscibility and shows that serine-rich or aromatic IDRs form miscible condensates, while highly charged IDRs form immiscible ones, with phosphorylation modulating this behavior.

This study shows PHF1 forms phase-separated condensates that recruit PRC2 to target loci, facilitating H3K27me3 deposition and transcription repression.

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.