Jianfeng Wu

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

This study shows that aldometanib activates AMPK to enhance CD8+ T cell infiltration and control hepatocellular carcinoma growth in immune-competent mice.

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.