Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease
Z. Lichner, M. Ding, T. Khare, Q. Dan, R. Benitez, M. Praszner, X. Song, R. Saleeb, B. Hinz, Y. Pei, K. Szaszi, A. Kapus
This study identifies MRTF as a key mediator of fibrosis in PKD by showing its activation following PC1/2 loss and its role in epithelial fibrogenesis.
bioRxiv · Mar 15, 2024 · PreprintCell Biology