Y. Pei

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease

This study identifies MRTF as a key mediator of fibrosis in PKD by showing its activation following PC1/2 loss and its role in epithelial fibrogenesis.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

Guanylate cyclase activity of TIR1/AFB auxin receptors mediates rapid auxin responses

The paper shows TIR1/AFB auxin receptors have both adenylate and guanylate cyclase activities, mediating transcriptional reprogramming and rapid Ca2+-dependent growth responses.

Teaching transposon classification as a means to crowd source the curation of repeat annotation - a tardigrade perspective

The paper presents a crowd-sourcing approach to manually curate and classify transposable elements (TEs) from tardigrade genomes, resulting in the discovery of hundreds of new TEs.

Plant immunity activated and suppressed by a conserved effector protein family in mirid bug Riptortus pedestris

RPH1, a conserved HAMP in herbivorous insects, activates plant PTI responses, but R. pedestris evolved four paralogs to suppress this immunity.

Organic matter influence on ooid formation: New insights into classic examples (Great Salt Lake, USA; Triassic Germanic Basin, Germany)

This study investigates ooid formation in two hypersaline environments, finding that organic matter plays a key role in their development, supported by structural and compositional analyses.

Spatial Localization Ability of Planarians Identified Through the Light Maze Paradigm

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

Diving Behavior Reveals Humidity Sensing Ability of Water Deprived Planarians

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

Novel leaf-root coordination driven by leaf water storage tissues in mangroves

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

Identification and current palaeobiological understanding of "Keratosa"-type non-spicular demosponge fossils in carbonates: with a new example from the lowermost Triassic, Armenia

The paper identifies and analyzes non-spicular demosponge fossils from the lowermost Triassic in Armenia, proposing criteria for their recognition and discussing their evolutionary significance.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

Cell detoxification of secondary metabolites by P4-ATPase mediated vesicle transport

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

Paleoecological implications of Lower-Middle Triassic stromatolites and microbe-metazoan build-ups in the Germanic Basin: Insights into the aftermath of the Permian - Triassic crisis

This study examines Triassic microbialites in the Germanic Basin to understand their formation and ecological significance after the Permian-Triassic crisis.

Late Anisian microbe-metazoan build-ups ('stromatolites') in the Germanic Basin -- aftermath of the Permian -- Triassic Crisis

This paper analyzes late Anisian stromatolites from the Germanic Basin, revealing they are microbe-metazoan build-ups formed by microbes and non-spicular demosponges, not purely microbial structures.

Machine learning reveals cryptic dialects that guide mate choice in a songbird

This study uses machine learning to uncover hidden song dialects in zebra finches that influence mate choice, showing cultural transmission drives assortative mating.

Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

This study shows that KSHV-encoded vCyclin modulates HIF1α levels in hypoxia to promote DNA replication and cell proliferation.

Sedimentary factories and ecosystem change across the Permian-Triassic Critical Interval (P-TrCI) - insights from the Xiakou area (South China)

This study examines sedimentary factories and ecosystem changes during the Permian-Triassic mass extinction in the Xiakou area, revealing asynchronous environmental and biodiversity shifts.

Offspring performance is well buffered against stress experienced by ancestors

This study investigates transgenerational effects of stress in zebra finches and finds no significant indirect effects, showing robustness against ancestral stress.

MRI tracking reveals selective accumulation of stem cell-derived magneto-extracellular vesicles in sites of injury

This study tracks stem cell-derived extracellular vesicles using MRI to show their selective accumulation at injury sites and protective effects in kidney injury models.

Proximate causes of infertility and embryo mortality in captive zebra finches

The paper investigates causes of infertility and embryo mortality in captive zebra finches, finding inbreeding, age-related decline, and poor nutrition significantly impact reproductive success, but explain only a small portion of the variance.