X. Song

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Towards Generalizability and Robustness in Biological Object Detection in Electron Microscopy Images

This study improves model generalizability in biological object detection using electron microscopy images through normalization and augmentation techniques, achieving a 29% average precision boost.

A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation.

This study identifies verteporfin as a potent CCL5/CCR5 axis antagonist that suppresses TNBC tumor growth and metastasis through CCR5-YAP1 regulation.

Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

Efficient semi-supervised semantic segmentation of electron microscopy cancer images with sparse annotations

The paper compares deep learning models for segmenting nuclei and nucleoli in cancer EM images using sparse labels and semi-supervised learning, showing improvements in 3D Dice scores.

Numerical simulation and analysis of droplet formation within an amphiphilic particle

The paper simulates droplet formation within amphiphilic particles using a 2D two-phase flow model to analyze how particle structure and parameters affect droplet trapping.

Selective refueling of CAR T cells using ADA1 and 1 CD26 boosts antitumor immunity

This study shows that engineering CAR T cells to co-express ADA1 and CD26 improves their antitumor activity by selectively refueling them with inosine in the tumor microenvironment.

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

Anti-PD-1-iRGD Peptide Conjugate Boosts Antitumor Efficacy via Engagement Augmentation and Penetration Enhancement of T cells

This paper develops a PD-1-iRGD conjugate that enhances antitumor efficacy by improving T cell engagement and penetration, and expands a unique population of CD8+ T cells in the tumor microenvironment.

EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

EZH2 inhibition increases immune checkpoint inhibitor response in lung squamous cell carcinomas by enhancing antigen presentation and immune cell infiltration.

Roles of Lipopolysaccharide Glycosyltransferases in Maintenance of Helicobacter pylori Morphology, Cell Wall Permeability, and Antimicobial Susceptibilities

This study investigates the roles of LPS glycosyltransferases in H. pylori morphology, cell wall permeability, and antimicrobial susceptibility, finding that their deletion alters morphology and increases susceptibility to certain antimicrobials.

Adaptor protein supersaturation drives innate immune signaling and cell fate

The paper identifies DFD adaptors as energy reservoirs through supersaturation, showing their role in innate immune signaling and cell fate decisions.

Long-B prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

Microbiome induced complement synthesized in the gut protects against enteric infections

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4

This paper identifies and characterizes SGC-CLK-1, a potent inhibitor of CLK1, CLK2, and CLK4, showing its selectivity and effects on SR protein phosphorylation and localization.

Methyl Halide Transferase-Based Gas Reporters for Quantification of Filamentous Bacteria in Microdroplet Emulsions

This paper introduces a methyl halide transferase-based gas reporter system to quantify filamentous bacteria in microdroplet emulsions, achieving higher sensitivity than optical methods.

Repurposing clemastine to target glioblastoma cell stemness

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

Expanding adult tubular microvessels on stiff substrates with endothelial cells and pericytes from the same tissue

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

A small-molecule lycorine derivative protects from obesity by targeting Na+/K+-ATPase α3 independent of food intake suppression

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

Integrative analysis of the MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX)

The paper characterizes the genomic and transcriptomic landscape of MDA PCa PDX models and develops an organoid platform to study prostate cancer heterogeneity and resistance.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Effects of seasonal changes on the carbon dynamics in mixed coniferous forests

This study examines seasonal changes in litter and soil carbon dynamics in mixed coniferous forests through freeze-thaw experiments, revealing how temperature fluctuations affect carbon release and mass loss.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.