Author

R. A. Lal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

A. S. Y. Poon· 2 shared E. A. Thomson· 2 shared H. Xu· 2 shared S. Lee· 2 shared A. I. d'Aquino· 1 shared B. A. Buckingham· 1 shared C. L. Maikawa· 1 shared D. M. Maahs· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

A. S. Y. Poon

Mutual co-authors in cluster

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3 papers

Recent·Most cited

β-Cells as a Cell Factory for On-Demand Recombinant Protein Dosing: Harnessing the Neuroendocrine Cell Secretory Pathway for Controlled Release

A. S. Y. Poon, J. Annes, E. A. Thomson, R. A. Lal, H. Xu, S. Lee

This paper develops a β-cell-based platform for on-demand recombinant protein delivery by modifying the endogenous insulin processing pathway to produce and release therapeutic peptides like GLP-1 or glucagon.

bioRxiv · Jan 20, 2024 · PreprintBioengineering

Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels

A. S. Y. Poon, J. P. Annes, R. A. Lal, E. A. Thomson, H. Xu, S. Lee, H. Moeller, J. Sands

Applying sub-minute pressure at physiological levels enhances therapeutic insulin transport from macroencapsulated islets, enabling rapid glucose regulation in diabetic rodent models.

bioRxiv · Dec 11, 2023 · PreprintBioengineering

Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats

C. L. Maikawa, P. C. Chen, E. T. Vuong, L. T. Nguyen, J. L. Mann, A. I. d'Aquino, R. A. Lal, D. M. Maahs, B. A. Buckingham, E. A. Appel

This study develops an ultra-fast insulin-pramlintide co-formulation that improves glucose management in diabetic rats by mimicking endogenous co-secretion and reducing patient burden.

bioRxiv · Apr 12, 2021Bioengineering