Author

J. L. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Organism:rat· 1

Frequent Co-Authors

C. L. Maikawa· 5 shared A. K. Grosskopf· 4 shared E. A. Appel· 4 shared A. I. d'Aquino· 2 shared D. M. Maahs· 2 shared E. Appel· 2 shared G. G. Fuller· 2 shared J. H. Klich· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersBioengineering

C. L. Maikawa

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Formulation excipients and their role in insulin stability and association state in formulation

C. L. Maikawa, L. T. Nguyen, J. L. Mann, E. A. Appel

This study investigates how excipients affect insulin stability and association state, finding that phenoxyethanol and specific copolymer concentrations enhance monomer content and stability in zinc-free insulin formulations.

bioRxiv · Aug 1, 2022Bioengineering

Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient

J. H. Klich, C. M. Kasse, J. L. Mann, Y. Huang, A. I. d'Aquino, A. K. Grosskopf, J. Baillet, G. G. Fuller, E. Appel

This paper introduces an amphiphilic copolymer excipient that enhances the stability of high-concentration monoclonal antibody formulations without affecting pharmacokinetics or injectability.

bioRxiv · May 25, 2022Bioengineering

Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

S. Correa, E. C. Gale, A. T. Mayer, Z. Xiao, C. Liong, J. H. Klich, R. A. Brown, E. L. Meany, O. M. Saouaf, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, J. Idoyaga, E. Appel

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

bioRxiv · Jun 27, 2021Bioengineering

Engineering Insulin Cold Chain Resilience to Improve Global Access

C. L. Maikawa, J. L. Mann, A. Kannan, C. M. Meis, A. K. Grosskopf, B. S. Ou, A. A. A. Smith, G. G. Fuller, D. M. Maahs, E. A. Appel

This paper develops amphiphilic copolymers to enhance insulin formulation resilience, enabling storage without refrigeration for over 6 months and improving global access to insulin.

bioRxiv · Apr 13, 2021Bioengineering

Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats

C. L. Maikawa, P. C. Chen, E. T. Vuong, L. T. Nguyen, J. L. Mann, A. I. d'Aquino, R. A. Lal, D. M. Maahs, B. A. Buckingham, E. A. Appel

This study develops an ultra-fast insulin-pramlintide co-formulation that improves glucose management in diabetic rats by mimicking endogenous co-secretion and reducing patient burden.

bioRxiv · Apr 12, 2021Bioengineering

Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors

D. Chan, J.-C. Chien, E. Axpe, L. Blankemeier, S. W. Baker, S. Swaminathan, V. A. Piunova, D. Y. Zubarev, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, H. T. Soh, E. A. Appel

This study develops combinatorial polyacrylamide hydrogels that outperform current anti-biofouling coatings in preventing biofouling on biosensors.

bioRxiv · May 25, 2020Bioengineering