BiophysicsbioRxiv
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
L. Adam, R. Kumar, L. E. Arroyo-Garcia…·A. Abelein
This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.
DOI 10.1002/pro.5091