Author

A. Abelein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Biverstal· 2 shared J. Johansson· 2 shared A. Farzadfard· 1 shared A. Fisahn· 1 shared A. Leppert· 1 shared A. Rising· 1 shared D. E. Otzen· 1 shared G. Chen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

H. Biverstal

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Author profile →

2 papers

Recent·Most cited

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

L. Adam, R. Kumar, L. E. Arroyo-Garcia, W. H. Molenkamp, J. S. Nowak, H. Klute, A. Farzadfard, R. Alkenayeh, J. Nielsen, H. Biverstal, D. E. Otzen, J. Johansson, A. Abelein

This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.

bioRxiv · Dec 7, 2023Biophysics

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

G. Chen, Y. Andrade-Talavera, X. Zhong, S. Hassan, H. Biverstal, H. Poska, A. Abelein, A. Leppert, N. Kronqvist, A. Rising, H. Hebert, P. J.B. Koeck, A. Fisahn, J. Johansson

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

bioRxiv · Dec 1, 2021 · PreprintBiochemistry