Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice
J. M. McLendon, X. Zhang, D. Matasic, M. Kumar, O. M. Koval, I. M. Grumbach, S. Sadayappan, B. London, R. Boudreau
This study shows that deleting Sorbs2 in cardiomyocytes causes dilated cardiomyopathy in mice, with defects in microtubule polymerization and structural proteins, and links Sorbs2 variants to human cardiac diseases.
bioRxiv · Feb 13, 2022 · PreprintPhysiology