Author

B. London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:electrophysiology· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J.-Y. Yoon· 3 shared K. Irani· 3 shared C. Brenner· 2 shared D. Matasic· 2 shared H. Mehdi· 2 shared J. M. McLendon· 2 shared A. Greiner· 1 shared A. M. Greiner· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPhysiology

J.-Y. Yoon

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Author profile →

4 papers

Recent·Most cited

SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability

J.-Y. Yoon, A. Greiner, J. S. Jacobs, Y.-R. Kim, T. P. Rasmussen, W. Kutschke, D. S. Matasic, A. Vikram, R. R. Gaddam, H. Mehdi, K. Irani, B. London

This study investigates how SUMOylation of NaV1.5 affects cardiac sodium current and electrophysiology, finding it increases peak INa without altering INa,L and may influence arrhythmic risk.

bioRxiv · Dec 26, 2022Physiology

Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice

J. M. McLendon, X. Zhang, D. Matasic, M. Kumar, O. M. Koval, I. M. Grumbach, S. Sadayappan, B. London, R. Boudreau

This study shows that deleting Sorbs2 in cardiomyocytes causes dilated cardiomyopathy in mice, with defects in microtubule polymerization and structural proteins, and links Sorbs2 variants to human cardiac diseases.

bioRxiv · Feb 13, 2022 · PreprintPhysiology

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

J.-Y. Yoon, N. Daneshgar, Y. Chu, B. Chen, M. Hefti, K. Irani, L.-S. Song, C. Brenner, E. D. Abel, B. London, D.-F. Dai

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

bioRxiv · Jan 4, 2022Pathology

Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors

D. Matasic, J.-Y. Yoon, J. M. McLendon, H. Mehdi, M. S. Schmidt, A. M. Greiner, P. Quinones, G. M. Morgan, R. L. Boudreau, K. Irani, C. Brenner, B. London

This study investigates how NAD+ precursors NR and NAM affect NaV1.5 currents and cardiac electrophysiology, finding NR increases peak INa and reduces INa,L while NAM has mixed effects.

bioRxiv · Feb 20, 2020Physiology