Author

S. Sadayappan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5 Cell Biology· 2 Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 6 Organism:mouse· 6 Research Focus:development & morphogenesis· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

T. Song· 3 shared W. Ma· 3 shared T. Irving· 2 shared A. Baby· 1 shared A. G. Jegga· 1 shared A. J. York· 1 shared A. K. Johansen· 1 shared A. L. Hessel· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersPhysiology

T. Song

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth

T. Song, J. McNamara, A. Baby, W. Ma, M. Landim-Vieira, S. Natesan, J. R. Pinto, J. N. Lorenz, T. Irving, S. Sadayappan

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.

bioRxiv · Oct 23, 2023 · PreprintPhysiology

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

A. L. Hessel, M. Kuehn, S.-W. Han, W. Ma, T. C. Irving, B. A. Momb, T. Song, S. Sadayappan, W. A. Linke, B. M. Palmer

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

bioRxiv · Oct 19, 2023 · PreprintPhysiology

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

W. Ma, V. Jani, T. Song, C. Gao, H. Gong, S. Sadayappan, D. A. Kass, T. Irving

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

bioRxiv · Oct 18, 2023 · PreprintBiophysics

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Y. Feng, L. Cai, M. Pook, F. Liu, C.-H. Chang, M. A. Mouti, R. Nibhani, S. Wu, S. Deng, S. Militi, J. Dunford, M. Philpott, Y. Fan, G.-C. Fan, Q. Liu, , S. Pauklin

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

bioRxiv · Mar 2, 2023Cancer Biology

Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle

S. R. Nelson, S. Beck-Previs, S. Sadayappan, C. Tong, D. Warshaw

This study investigates the role of MyBP-C in stabilizing the SRX myosin state in cardiac muscle using transgenic mice and super-resolution microscopy, finding that MyBP-C's N-terminal region is critical for maintaining SRX along the thick filament.

bioRxiv · Oct 3, 2022Physiology

Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice

J. M. McLendon, X. Zhang, D. Matasic, M. Kumar, O. M. Koval, I. M. Grumbach, S. Sadayappan, B. London, R. Boudreau

This study shows that deleting Sorbs2 in cardiomyocytes causes dilated cardiomyopathy in mice, with defects in microtubule polymerization and structural proteins, and links Sorbs2 variants to human cardiac diseases.

bioRxiv · Feb 13, 2022 · PreprintPhysiology

Identification of CD4+ Sub-population of Resident Cardiac Fibroblasts Linked to Myocardial Fibrosis

J. H. Siamwala, F. Pagano, P. M. Dubielecka, A. Zhao, S. Chen, H. Granston, S. Rounds, S. Sadayappan, R. J. Gilbert

The paper identifies a CD4+ subpopulation of resident cardiac fibroblasts linked to myocardial fibrosis, showing their transdifferentiation from mesenchymal to lymphoid-like cells via the IL-1β-IL-1R-NFκB pathway.

bioRxiv · Feb 26, 2021 · PreprintImmunology

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

F. Xiao, N. Lam, P. Wang, S. Li, D. Canseco, W. Kimura, X. Luo, N. U. N. Nguyen, W. El Helaly, R. Singh, S. Sadayappan, M. Kanchwala, C. Xing, R. Hajjar, J. Hill, H. Sadek

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

bioRxiv · Dec 24, 2020Cell Biology

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS

A. Li, S. Nelson, S. Rahmanseresht, F. Braet, A. S. Cornachione, S. B. Previs, T. S. O'Leary, J. W. McNamara, D. E. Rassier, S. Sadayappan, M. J. Previs, D. M. Warshaw

This study examines how different MyBP-C isoforms affect contractility in fast- and slow-twitch skeletal muscles using proteomic, biophysical, and modeling approaches.

bioRxiv · Jun 21, 2019Physiology

An acute immune response underlies the benefit of cardiac adult stem cell therapy

R. Vagnozzi, M. Maillet, M. Sargent, H. Khalil, A. K. Johansen, J. Schwanekamp, A. J. York, V. Huang, M. Nahrendorf, S. Sadayappan, J. D. Molkentin

This study shows that cardiac adult stem cell therapy improves heart function through an acute immune response involving macrophages, not by regenerating cardiomyocytes.

bioRxiv · Dec 26, 2018Cell Biology