Author

R. Britton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kaghad· 1 shared A. Li· 1 shared C. Arrowsmith· 1 shared C. Scholten· 1 shared D. Barsyte· 1 shared D. Panagopoulos· 1 shared D. Smil· 1 shared D. Zhu· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Kaghad

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Control of Clostridiodes difficile virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility

D. Zhu, K. Wozniak, F. S. Midani, S. Wang, X. Sun, R. Britton

This study investigates the role of the FliC-FliW-CsrA network in C. difficile virulence and physiology, showing that these proteins regulate toxin production and metabolism even in non-motile strains.

bioRxiv · Nov 8, 2022 · PreprintMicrobiology

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

M. Sutherland, A. Li, A. Kaghad, D. Panagopoulos, F. Li, M. Szewczyk, D. Smil, C. Scholten, L. Bouche, T. Stellfeld, C. Arrowsmith, D. Barsyte, M. Vedadi, I. V. Hartung, H. Steuber, , V. Santhakumar

This study designs and synthesizes a new class of selective PRMT4 inhibitors with improved selectivity over other PRMT family members.

bioRxiv · Nov 17, 2020Pharmacology & Toxicology