Author

D. Barsyte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

F. Li· 2 shared M. Szewczyk· 2 shared M. Vedadi· 2 shared A. Dong· 1 shared A. Kaghad· 1 shared A. Li· 1 shared C. Arrowsmith· 1 shared C. C. dela Sena· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

F. Li

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Author profile →

2 papers

Recent·Most cited

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

M. Sutherland, A. Li, A. Kaghad, D. Panagopoulos, F. Li, M. Szewczyk, D. Smil, C. Scholten, L. Bouche, T. Stellfeld, C. Arrowsmith, D. Barsyte, M. Vedadi, I. V. Hartung, H. Steuber, , V. Santhakumar

This study designs and synthesizes a new class of selective PRMT4 inhibitors with improved selectivity over other PRMT family members.

bioRxiv · Nov 17, 2020Pharmacology & Toxicology

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

X.-C. Cai, T. Zhang, E.-j. Kim, M. Jiang, K. Wang, J. Wang, S. Chen, N. Zhang, H. Wu, F. Li, C. C. dela Sena, H. Zheng, V. Vivcharuk, X. Niu, W. Zheng, , M. Luo

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

bioRxiv · Mar 27, 2019Biochemistry