BiochemistrybioRxiv
Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains
K. T. Elvers, M. Lipka-Lloyd, R. C. Trueman…·Y. Mehellou
The paper determines the crystal structures of human SPAK and OSR1 CCT domains and measures their binding affinity to a WNK4 peptide, providing a basis for designing inhibitors targeting SPAK-activation.
DOI 10.1002/cbic.202100441