BiophysicsbioRxivPreprint
A 2.8A structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase
H. Morgan, M. Lipka-Lloyd, A. J. Warren…·B. D. Bax
This paper reports the 2.8Å X-ray structure of zoliflodacin bound to Staphylococcus aureus DNA gyrase, showing its mechanism of DNA cleavage inhibition and improved antibacterial activity.
DOI 10.1101/2022.11.30.518515