Pharmacology & ToxicologybioRxiv
Translational predictions of phase 2a first-in patient efficacy studies for antituberculosis drugs
R. M. Savic, J. J. N. Goh, J. P. Ernest…·E. Nuermberger
The paper predicts clinical efficacy of antituberculosis drugs using preclinical PKPD data and translational pharmacology models to reduce phase 2a trial costs and failures.
DOI 10.1183/13993003.00165-2023