Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
E. Gruber, J. So, A. C. Lewis, R. Franich, R. Cole, L. G. Martelotto, A. J. Rogers, E. Vidacs, P. Fraser, K. Stanley, L. Jones, A. S. Trigos, N. Thio, J. Li, B. Nicolay, , L. M. Kats
This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.
bioRxiv · Apr 6, 2022Cancer Biology