Author

R. J. Kishton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

N. P. Restifo· 3 shared D. C. Deniger· 2 shared D. C. Palmer· 2 shared D. Gurusamy· 2 shared P. Malekzadeh· 2 shared S. J. Patel· 2 shared S. K. Vodnala· 2 shared W. Lo· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

N. P. Restifo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivSep 24, 2020

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

D. C. Palmer, B. R. Webber, Y. Patel…·N. P. Restifo

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

DOI 10.1016/j.medj.2022.07.008

𝕏 PostBluesky

Cancer BiologybioRxivMar 13, 2020

Genome-wide Screens Identify Lineage- and Tumor Specific-Genes Modulating MHC-I and MHC-II Immunosurveillance in Human Lymphomas

D. Dersh, J. D. Phelan, M. E. Gumina…·J. W. Yewdell

The paper identifies genes modulating MHC-I and MHC-II expression in lymphomas, revealing potential targets for immunosurveillance manipulation.

DOI 10.1016/j.immuni.2020.11.002

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintNov 18, 2019

Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy

R. J. Kishton, S. J. Patel, S. K. Vodnala…·N. P. Restifo

This study identifies genes that tumor cells use to resist T cell killing and shows that inhibiting BIRC2, ITGAV, or DNPEP enhances T cell-mediated tumor destruction.

DOI 10.1101/843185

humanwhole-genome sequencing

𝕏 PostBluesky