Cancer BiologybioRxiv
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
X. Y. Woo, J. Giordano, A. Srivastava…·B. E Welm
This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.