A. Bertotti

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

XENTURION, a multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients for population-level translational oncology

XENTURION provides a resource of PDX models and tumoroids from metastatic CRC patients, revealing variable cetuximab responses and identifying therapeutic targets through cross-platform validation.

Drug-induced colorectal cancer persister cells show increased mutation rate

The paper shows that drug treatment induces colorectal cancer persister cells with significantly increased mutation rates, suggesting new strategies to prevent tumor recurrence.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

This study tracks neoantigen profiles in colorectal cancers with DNA repair defects, finding dynamic patterns linked to antigen presentation downregulation and evolvability.