Author

R. K. Arni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

R. J. Eberle· 3 shared D. S. Olivier· 2 shared D. Willbold· 2 shared M. A. Coronado· 2 shared M. S. Amaral· 2 shared B. Stuqui· 1 shared F. R. de Moraes· 1 shared H. Schaal· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

R. J. Eberle

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivJan 15, 2022

The secreted metabolome of HeLa cells under effect of Crotamine, a cell-penetrating peptide from a rattlesnake using NMR-based metabolomics analyses

M. A. Coronado, F. R. de Moraes, B. Stuqui…·R. K. Arni

This study uses NMR-based metabolomics to analyze how Crotamine affects the secreted metabolome of HeLa cells, revealing changes in glycolysis and related pathways.

DOI 10.3390/biomed2020020

humanmetabolomics

𝕏 PostBluesky

BiochemistrybioRxivNov 10, 2021

Design of D-amino acids SARS-CoV-2 Main protease inhibitors using the cationic peptide from rattlesnake venom as a scaffold

R. J. Eberle, I. Gering, M. Tusche…·M. Coronado

The paper designs D-amino acid-based inhibitors of SARS-CoV-2 3CLpro using a rattlesnake venom peptide scaffold, showing in vitro and in vivo antiviral activity.

DOI 10.3390/ph15050540

protein sequenceexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivNov 11, 2020

The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

R. J. Eberle, D. S. Olivier, M. S. Amaral…·M. A. Coronado

This study shows that quinacrine and suramin inhibit SARS-CoV-2 3CLpro synergistically in vitro through competitive and non-competitive mechanisms.

DOI 10.3390/v13050873

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky