S. Sen

Eugenol loaded lipid nanoparticles derived hydrogels ameliorate psoriasis-like skin lesions by lowering oxidative stress and modulating inflammation

This paper develops eugenol-loaded lipid nanoparticles in hydrogels to treat psoriasis by reducing oxidative stress and inflammation, showing significant improvement in psoriasis symptoms.

Transcutaneous delivery of disease specific PI3K/Akt/mTOR inhibitor based hybrid nanoparticles in hydrogel system for the management of psoriasis: Insights from in vivo studies

This paper develops a hybrid nanoparticle-hydrogel system for psoriasis treatment, showing improved drug delivery and reduced PASI scores in vivo.

CD44/Integrin β1 association drives fast motility on HA substrates

This study shows that CD44/Integrin β1 association enables faster cell motility on HA substrates by forming smaller, weaker focal adhesions.

Condensin II activation by M18BP1

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

Genomic surveillance reveals that the dengue 2 virus lineage responsible for the 2023-2024 epidemic in the French Caribbean Islands is resistant to Mosnodenvir

The paper identifies a mutation in dengue virus genomes from the 2023-2024 French Caribbean epidemic that confers resistance to the anti-dengue compound mosnodenvir.

Two distinct integrin binding sites on MMP9 drive cancer invasion by mediating integrin membrane trafficking & stabilization

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Fermented polyherbal formulation restored ricinoleic acid-induced diarrhea in Sprague Dawley rats and exhibited in vitro antibacterial effect on multiple antibiotics resistant gastric pathogens

This paper evaluates a polyherbal formulation AP-01 for treating ricinoleic acid-induced diarrhea in rats and demonstrates its in vitro antibacterial activity against antibiotic-resistant gastric pathogens.

Fermented polyherbal formulation ameliorates the severity of acute multiple - antibiotics - resistant Pseudomonas aeruginosa infected burn wound in rat burn model

This paper evaluates a fermented polyherbal formulation's efficacy in reducing burn wound severity caused by multiple-antibiotic-resistant Pseudomonas aeruginosa in a rat model.

Bulky glycocalyx drives cancer invasiveness by modulating substrate-specific adhesion

This study shows that MUC1 expression levels modulate breast cancer cell motility and invasiveness through substrate-specific adhesion mechanisms.

Measuring RBC deformability and its heterogeneity using a fast microfluidic device

The paper introduces a microfluidic device to measure RBC deformability and Young's modulus, showing stiffer RBCs deflect more and enabling sorting based on deformability.

Localized measurements of water potential reveal large loss of conductance in living tissues of maize leaves

The paper measures localized water potential in maize leaf tissues, revealing significant hydraulic conductance loss in the OXZ and its role in regulating transpiration.

Adventitial macrophage accumulation impairs perivascular nerve function in mesenteric arteries with inflammatory bowel disease

This study shows that adventitial macrophage accumulation in mesenteric arteries with IBD impairs perivascular nerve function, particularly sensory vasodilation, which is reversed by macrophage depletion.

Differential transpiration between pods and leaves during stress combination in soybean

The paper shows that soybean pods and leaves exhibit differential transpiration under combined water deficit and heat stress, reducing internal pod temperature and protecting seed development.

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

This study integrates genomic and transcriptomic analysis of intraductal papillary mucinous neoplasms (IPMNs) to identify molecular features associated with progression to high-grade lesions and cancer.

ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

This study uses ultrafast crystallography to reveal how photoactivated retinal initiates structural changes in rhodopsin, leading to GPCR activation and vision.

Plasma Proteome Perturbation for CMV DNAemia in Kidney Transplantation

The paper identifies plasma proteomic changes associated with CMV DNAemia in kidney transplant recipients, revealing biomarkers for disease prediction and immune pathway insights.

Cytoplasmic membrane thinning observed by interfacial dyes is likely a common effect of bactericidal antibiotics

The paper uses membrane-specific dyes to measure antibiotic-induced membrane damage in E. coli and ESKAPE pathogens, finding that cytoplasmic membrane thinning correlates with bactericidal antibiotic sensitivity.

On the Interaction of Biopotential Sensing and Right Leg Drive System with Electro-Quasistatic Human Body Communication

This paper investigates how HBC and RLD interact, showing HBC does not affect biopotential sensing but RLD weakens HBC signals, proposing to avoid RLD for HBC-based biosensors.

Bi-Phasic Quasistatic Brain Communication for Fully Untethered Connected Brain Implants

This paper introduces BP-QBC, a new wireless communication method for brain implants that achieves low end-to-end channel loss and high data rates using electro-quasistatic signaling.

Deep Immunophenotyping Reveals Endometriosis is Marked by Dysregulation of the Mononuclear Phagocytic System in Endometrium and Peripheral Blood

This study uses mass cytometry to analyze immune cell phenotypes in endometriosis patients, finding dysregulated mononuclear phagocytic system in endometrium and blood.

Differential regulation of flower transpiration during abiotic stress in plants

The paper shows that under drought and heat stress, soybean plants open flower stomata to lower flower temperature, protecting reproduction at the expense of vegetative tissues.

Are reaching and grasping effector-independent? Similarities and differences in reaching and grasping kinematics between the hand and foot

The paper investigates whether reaching and grasping kinematics are effector-independent by comparing hand and foot movements, finding shared ballistic phases but differences in deceleration and grip aperture timing.

Ligand geometry dictates cellular and in vivo uptake of 3D DNA nanostructures

This study investigates how the geometry of 3D DNA nanostructures affects their cellular and in vivo uptake, finding that tetrahedral shapes are more efficiently internalized.

Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1

The paper shows that the N-terminus of hCTR1 regulates copper uptake by coordinating Cu(I) and facilitating its reduction from Cu(II).

-actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization

This study shows ACTN4 regulates cancer cell invasiveness by controlling NMM IIB expression and NMM IIA localization during 3D invasion.

Pre-metastatic niche drives breast cancer invasion by modulating MSC homing and CAF differentiation

The paper shows that pre-metastatic niche modulates MSC homing and CAF differentiation, promoting breast cancer invasion and metastasis.

The novel leishmanial Copper P-type ATPase plays a vital role in intracellular parasite survival

This study identifies and characterizes the Leishmania major Cu-ATPase, LmATP7, and demonstrates its role in copper stress resistance and parasite survival within macrophages.

Bio-Physical Modeling of Galvanic Human Body Communication in Electro-Quasistatic Regime

This paper develops a detailed lumped element model for Galvanic Human Body Communication (HBC) to analyze channel loss factors like tissue properties, electrode configuration, and return path capacitance.