Author

R. Lithgo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:virus· 1

Frequent Co-Authors

A. Croft· 1 shared A. Orville· 1 shared A. Quigley· 1 shared A. S. de Godoy· 1 shared A. V. Chandran· 1 shared B. H. Balcomb· 1 shared C. Girould· 1 shared C. Jager· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Croft

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

X. Ni, R. B. Richardson, A. S. de Godoy, M. P. Ferla, C. Kikawa, J. Scheen, W. W. Hannon, E. Capkin, N. Lahav, B. H. Balcomb, P. G. Marples, M. Fairhead, S. Wang, E. Williams, C. W. E. Tomlinson, , F. von Delft

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry

The adaptability of the ion binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF.

R. Lithgo, M. Hanzevacki, G. Harris, J. Kamps, E. Holden, J. L. Benesch, C. Jager, A. Croft, J. Hobman, A. Orville, A. Quigley, S. Carr, D. Scott

This study shows SilF, a periplasmic chaperone, binds both Ag(I) and Cu(I) with similar affinities, suggesting Gram-negative bacteria use an existing Cu(I) detox system for Ag(I) resistance.

bioRxiv · Mar 31, 2023Biophysics