D. Scott

Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure

This study compares SARS-CoV-2 replication in rhesus macaques after intranasal inoculation or aerosol exposure, finding differences in respiratory tract involvement.

The adaptability of the ion binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF.

This study shows SilF, a periplasmic chaperone, binds both Ag(I) and Cu(I) with similar affinities, suggesting Gram-negative bacteria use an existing Cu(I) detox system for Ag(I) resistance.

Molecular Dynamics simulation of TDP-43 RRM in the presence and absence of RNA

This study uses molecular dynamics simulations to analyze TDP-43 RRM domains in the absence of RNA and compares them to RNA-bound structures to identify potential druggable sites.

Severe acute respiratory disease in American mink (Neovison vison) experimentally infected with SARS-CoV-2

This study shows that SARS-CoV-2 infected mink develop severe respiratory disease with features similar to severe acute respiratory disease in humans.

A pigtailed macaque model for Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus

This paper establishes a pigtailed macaque model for KFDV and AHFV that replicates human disease symptoms and viral tropism.

Immunocompetent Mouse Model for Crimean-Congo Hemorrhagic Fever Virus

This paper develops an immunocompetent mouse model for CCHFV that replicates human disease severity, enabling better study of host-viral interactions.

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2

This study shows that SARS-CoV-2 causes respiratory disease in rhesus macaques with symptoms similar to human cases, including prolonged viral shedding.