Author

R. Luc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Apostolou· 2 shared D. V. Manatakis· 2 shared G. A. Hamilton· 2 shared K. Karalis· 2 shared A. Banerjee· 1 shared A. Dimitriou· 1 shared A. N. Lewis· 1 shared B. Bleck· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioengineering

A. Apostolou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microfluidic Device Facilitates Novel In Vitro Modeling of Human Neonatal Necrotizing Enterocolitis-on-a-Chip

W. E. Lanik, C. J. Luke, L. S. Nolan, Q. Gong, J. M. Rimer, S. E. Gale, R. Luc, S. S. Bidani, C. A. Sibald, A. N. Lewis, B. Mihi, P. Agrawal, M. Goree, M. Maestas, E. Hu, , M. Good

The paper introduces a microfluidic model of human neonatal small intestinal epithelium to study NEC, showing inflammation, barrier disruption, and epithelial dysfunction.

bioRxiv · Nov 29, 2020Cell Biology

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

A. Apostolou, R. Panchakshari, A. Banerjee, D. V. Manatakis, M. D. Paraskevopoulou, R. Luc, G. Abu Ali, A. Dimitriou, C. Lucchesi, G. Kulkarni, T. I. Maulana, B. Bleck, E. S. Manolakos, G. A. Hamilton, C. Giallourakis, K. Karalis

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

bioRxiv · Aug 28, 2020 · PreprintBioengineering

Organoid-derived Duodenum Intestine-Chip for preclinical drug assessment in a human relevant system

M. Kasendra, R. Luc, J. Yin, D. V. Manatakis, A. Apostolou, L. Sunuwar, J. Obrigewitch, G. A. Hamilton, M. Donowitz, K. Karalis

The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.

bioRxiv · Aug 5, 2019Cell Biology