D. V. Manatakis

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

The paper presents a human Brain-Chip that models neuroinflammation by recapitulating brain cell interactions and BBB function, showing improved complexity and clinical relevance compared to existing models.

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

The paper develops a human Brain-Chip model of Parkinson's disease to study blood-brain barrier disruption and synucleinopathy mechanisms.

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.