Author

C. Lucchesi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Apostolou· 2 shared G. A. Hamilton· 2 shared G. Kulkarni· 2 shared J. Sliz· 2 shared K. Karalis· 2 shared A. Banerjee· 1 shared A. C. Rizos· 1 shared A. Dimitriou· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Apostolou

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

L. Ewart, A. Apostolou, S. A. Briggs, C. V. Carman, J. T. Chaff, A. R. Heng, S. Jadalannagari, J. Janardhanan, K.-J. Jang, S. R. Joshipura, M. Kadam, M. Kanellias, V. J. Kujala, G. Kulkarni, C. Y. Le, , D. Levner

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

bioRxiv · Dec 14, 2021 · PreprintPharmacology & Toxicology

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

A. Apostolou, R. Panchakshari, A. Banerjee, D. V. Manatakis, M. D. Paraskevopoulou, R. Luc, G. Abu Ali, A. Dimitriou, C. Lucchesi, G. Kulkarni, T. I. Maulana, B. Bleck, E. S. Manolakos, G. A. Hamilton, C. Giallourakis, K. Karalis

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

bioRxiv · Aug 28, 2020 · PreprintBioengineering

A novel Organ-Chip system emulates three-dimensional architecture of the human epithelia and allows fine control of mechanical forces acting on it.

A. VARONE, J. K. Nguyen, L. Leng, R. Barrile, J. Sliz, C. Lucchesi, N. Wen, A. Gravanis, G. A. Hamilton, K. C. Karalis, C. D. Hinojosa

This paper introduces a new Organ-Chip system that emulates the 3D architecture of human epithelia and allows precise control of mechanical forces, demonstrating its feasibility with skin and alveolar epithelial cells.

bioRxiv · Aug 2, 2020Bioengineering

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

J. C. Nawroth, C. Lucchesi, D. Cheng, A. Shukla, J. Nguyen, T. Shroff, K. Karalis, H.-H. Lee, S. Alves, G. Hamilton, M. Salmon, R. Villenave

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

bioRxiv · Feb 2, 2020Bioengineering