Cell BiologybioRxivPreprint
4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis
T. Levy, K. Voeltzke, L. Hauffe…·G. Leprivier
This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.