A. Schulze

Physiologically refined cell culture conditions uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroids

This study improves Ewing sarcoma cell culture conditions to better reflect physiological states, revealing metabolic gene signatures linked to oncogenic fusion proteins.

The core microbiome of cultured Pacific oyster spat develops with age but not mortality

This study shows that the core microbiome of Pacific oyster spat develops with age but not mortality, and is influenced by environmental dispersal.

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer cells

This paper introduces 13C-SpaceM, a method for spatial single-cell isotope tracing of de novo fatty acid synthesis in cancer cells, revealing metabolic heterogeneity in liver and glioma tissues.

Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

This study shows cancer-associated fibroblasts enhance drug resistance in ALK-driven lung adenocarcinoma by promoting lipid biosynthesis and suppressing lipid peroxidation through AKT signaling.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

The potent broadly neutralizing antibody VIR-3434 controls Hepatitis B and D Virus infection and reduces HBsAg in humanized mice

This paper identifies a potent anti-HBs mAb, VIR-3434, that neutralizes HBV and HDV and reduces HBsAg and viremia in human liver-chimeric mice.

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

c-Myc plays a key role in IFN-γ induced persistence of Chlamydia trachomatis

This study shows that IFN-γ induces Chlamydia persistence by depleting c-Myc, which is regulated by the PI3K-GSK3β axis and L-tryptophan levels, challenging the IDO depletion hypothesis.

A central role of glutamine in Chlamydia infection

This study identifies glutamine as essential for Chlamydia's EB-RB transition and shows that host glutamine metabolism is reprogrammed to support bacterial growth.

Shoot-to-root translocation of the jasmonate precursor 12-oxo-phytodienoic acid (OPDA) coordinates plant growth responses following tissue damage

This study identifies OPDA as a mobile jasmonate precursor that translocates from damaged shoots to roots, coordinating growth responses in Arabidopsis.

Accuracy, limitations and cost-efficiency of eDNA-based community survey in tropical frogs

This study evaluates the accuracy and cost-efficiency of eDNA-based surveys for tropical frog communities, finding good agreement with field surveys and cost-effectiveness in high-diversity areas.