Author

C.-C. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 2 Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. Chen· 3 shared M.-Y. Lin· 3 shared T.-Y. Kuo· 3 shared W.-H. Tang· 3 shared Y.-J. Lin· 3 shared J. Cheng· 2 shared J. D. Campbell· 2 shared L. T. C. Liu· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

C. Chen

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Author profile →

10 papers

Recent·Most cited

Structural Basis of How MGME1 Processes DNA 5' Ends to Maintain Mitochondrial Genome Integrity

E. Y. C. Mao, H.-Y. Yen, C.-C. Wu

This study determines the structural mechanism of MGME1's 5'-end DNA processing, revealing its bidirectional exonuclease activity and role in mtDNA maintenance.

bioRxiv · Jan 15, 2024Biochemistry

Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma (DMG)

O. Padilla, H. E. Minns, H.-J. Wei, W. Fan, A. Webster-Carrion, M. Tazhibi, N. M. McQuillan, X. Zhang, M. Gallitto, R. Yeh, Z. Zhang, T. K. Hei, L. Szalontay, J. Pavisic, Y. Tan, , R. D. Gartrell

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

bioRxiv · Nov 9, 2022Immunology

Neutralization of SARS-CoV-2 Omicron BA.4/BA.5 subvariant by a booster dose of bivalent adjuvanted subunit vaccine containing Omicron BA.4/BA.5 and BA.1 subvariants

T.-Y. Kuo, C. E. Lien, Y.-J. Lin, M.-Y. Lin, L. T.-C. Liu, C.-C. Wu, W.-H. Tang, C. Chen

This study evaluates the effectiveness of a bivalent subunit vaccine containing Omicron BA.4/BA.5 and BA.1 subvariants as a booster, finding it provides the highest neutralizing titers against BA.4/BA.5 in mice.

bioRxiv · Oct 7, 2022 · PreprintImmunology

Computer simulations reveal pathogenicity and inheritance modes of hearing loss-causing germinal variants

C.-Y. Tsai, Y.-C. Lu, Y.-H. Chan, Y.-Y. Chang, S.-W. Lin, T.-C. Liu, C.-J. Hsu, P.-L. Chen, L.-W. Yang, C.-C. Wu

The paper uses molecular dynamics simulations to show how GJB2 variants cause hearing loss by altering ion channel function and demonstrates a recessive inheritance pattern in mice.

bioRxiv · May 2, 2022 · PreprintBiophysics

The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

S.-E. Lamhamedi-Cherradi, M. Maitituoheti, B. A. Menegaz, S. Krishnan, A. M. Vetter, P. Camacho, C.-C. Wu, H. C. Beird, R. W. Porter, D. R. Ingram, V. Ramamoorthy, S. Mohiuddin, D. McCall, D. D. Truong, B. Cuglievan, , J. A. Ludwig

The paper shows that DSRCT is driven by the androgen receptor and responds to androgen deprivation therapy.

bioRxiv · Jan 20, 2022Cancer Biology

Protection of Hamsters Challenged with SARS-CoV-2 Variants of Concern by Two Doses of MVC-COV1901 Vaccine Followed by a Single Dose of Beta Variant Version of MVC-COV1901

T.-Y. Kuo, C.-E. Lien, Y.-J. Lin, M.-Y. Lin, C.-C. Wu, W.-H. Tang, J. D. Campbell, P. Traquina, Y.-S. Chuang, L. T. C. Liu, J. Cheng, C. Chen

This study evaluates the efficacy of a vaccine regimen using wildtype and Beta variant S-2P in hamsters against SARS-CoV-2 Delta and VoCs, showing improved neutralization and protection with a mixed-dose schedule.

bioRxiv · Sep 29, 2021 · PreprintImmunology

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

T.-Y. Kuo, M.-Y. Lin, R. L. Coffman, J. D. Campbell, P. Traquina, Y.-J. Lin, L. T. C. Liu, J. Cheng, Y.-C. Wu, C.-C. Wu, W.-H. Tang, C.-G. Huang, K.-C. Tsao, S.-R. Shih, C. Chen

This paper develops a subunit vaccine against COVID-19 using CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen and shows it induces high neutralizing antibody titers and Th1 response in mice.

bioRxiv · Aug 11, 2020Immunology

Correlation between cancer stem cells, inflammation and malignant transformation in a DEN-induced model of hepatic carcinogenesis

C.-C. Wu, C.-J. Lin, K.-K. Kuo, W.-T. Chen, C.-G. Ker, C.-Y. Chai, H.-P. Tsai, S.-F. Yang

bioRxiv · Apr 17, 2020 · PreprintCancer Biology

In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

C.-C. Wu, A. Klaesson, J. Buskas, P. Ranefall, R. Mirzazadeh, O. Söderberg, J. B. W. Wolf

The paper quantifies individual mRNA transcripts in melanocytes to reveal gene regulation differences in feather pigment synthesis between hooded crows and black crows.

bioRxiv · May 28, 2018Evolutionary Biology

Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus

C.-C. Wu, X. Jiang, X.-Z. Wang, X.-J. Liu, X.-J. Li, B. Yang, H.-Q. Ye, T. Harwardt, M. Jiang, H.-M. Xia, W. Wang, W. J. Britt, C. Paulus, M. Nevels, M.-H. Luo

This study shows HCMV IE1 protein causes SOX2 loss in NPCs by trapping unphosphorylated STAT3 in the nucleus, leading to neurodevelopmental damage.

bioRxiv · Apr 25, 2018Microbiology