Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function
K. A. Dietze, K. Nguyen, A. Pathni, F. Fazekas, W. Sun, E. Rosati, J. M. Baker, M. Galeana Figueroa, E. Gebru, D. Yamoah, R. Mulatu, A. Wang, A. P. Rapoport, D. Lum, X. Fan, , T. Luetkens
This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.
bioRxiv · Jun 11, 2024Bioengineering