A. Upadhyaya

This study shows that N-WASP-dependent branched actin polymerization drives B-cell contraction, which reduces BCR signaling by increasing receptor cluster molecular density and displacing signaling molecules.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

This study uses single-molecule tracking and machine learning to identify two low-mobility states of chromatin and transcriptional regulators, showing dynamic interactions and switching between states.

The paper uses simulations and experiments to show that actin ring formation in cells depends on the balance between filament treadmilling and myosin contractility.

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This study compares the immunogenicity of soluble trimeric influenza stem domain immunogens and nanoparticle-displayed versions, showing similar protection against homologous and heterologous viral challenges.

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

The paper analyzes single-molecule tracking data of transcription factors and finds power-law distributions, suggesting a continuum affinity model rather than discrete binding states.

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

This paper introduces faster deconvolution and multiview fusion methods, achieving speedups of 10 to several thousand-fold over previous approaches.

This study uses single molecule imaging and machine learning to show that N-WASP regulates BCR and co-receptor mobility during signaling, affecting actin dynamics and B cell responses.

This paper introduces a method combining instant structured illumination microscopy with TIRF to achieve higher resolution and faster imaging of live samples near the coverslip.

This paper introduces a reflective imaging technique that enhances resolution, speed, and collection efficiency in light sheet microscopy without altering the microscope hardware.