Author

R. P. Joosten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Research Focus:benchmarking· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Perrakis· 3 shared A. Koch· 1 shared B. van Beusekom· 1 shared F. Tsakou· 1 shared G. L. Gilliland· 1 shared G. Rajagopal· 1 shared J. Luo· 1 shared M. L. Hekkelman· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

A. Perrakis

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Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivMar 26, 2020

A global Ramachandran score identifies protein structures with unlikely stereochemistry

O. V. Sobolev, P. V. Afonine, N. W. Moriarty…·P. D. Adams

The paper introduces a re-implemented Ramachandran Z-score and its uncertainty estimation for protein structure validation, advocating its inclusion in structural publications and validation reports.

DOI 10.1016/j.str.2020.08.005

protein structurestatistical model

𝕏 PostBluesky

BiochemistrybioRxivJul 18, 2017

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

Y. Hiruma, A. Koch, N. Hazraty…·A. Perrakis

The paper characterizes inhibitor resistance in Mps1 mutants using biophysical assays and crystal structures, showing that Cpd-5 is better tolerated than NMS-P715 in resistant mutants.

DOI 10.1074/jbc.m117.783555

protein structurebiophysical modeling

𝕏 PostBluesky

BiochemistrybioRxivJun 21, 2017

Homology-based hydrogen bond information improves crystallographic structures in the PDB

B. van Beusekom, W. G. Touw, M. Tatineni…·R. P. Joosten

The paper improves low-resolution crystallographic structures by incorporating homology-derived hydrogen bond restraints.

DOI 10.1002/pro.3353

protein structuredeep learning

𝕏 PostBluesky