Author

R. Ritchie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:metabolomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

M. P. Barrett· 4 shared E. A. Dickie· 2 shared R. J. S. Burchmore· 2 shared A. J. M. Wollman· 1 shared A. M. Donachie· 1 shared A. Schnaufer· 1 shared A. W. Pountain· 1 shared B. Wickstead· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

M. P. Barrett

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Author profile →

4 papers

Recent·Most cited

Ovothiol is a redundant part of a complex thiol network in promastigote Leishmania mexicana

V. L. Bolton, L. L. Morrison, S. Khanra, R. Ritchie, K. E. Hargrave, R. J. S. Burchmore, M. K. L. MacLeod, M. P. Barrett

This paper shows that OvoA, an enzyme involved in ovothiol synthesis in Leishmania mexicana, is not essential for growth or infectivity but affects sensitivity to amphotericin B.

bioRxiv · Dec 8, 2023 · PreprintBiochemistry

Kasturi Haldar, Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

E. A. Alpizar-Sosa, N. R. Binti Ithnin, W. Wei, A. W. Pountain, S. K. Weidt, A. M. Donachie, R. Ritchie, E. A. Dickie, R. J. S. Burchmore, P. W. Denny, M. P. Barrett

This study identifies genetic and metabolic changes in Leishmania mexicana lines resistant to amphotericin B, revealing mutations in sterol metabolism genes and altered oxidative stress responses.

bioRxiv · Dec 8, 2021 · PreprintMicrobiology

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential drug sensitivity

P. C. Steketee, E. A. Dickie, J. Iremonger, K. Crouch, E. Paxton, S. Jayaraman, O. A. Alfituri, G. Awuah-Mensah, R. Ritchie, A. Schnaufer, H. De Koning, C. Gadelha, B. Wickstead, M. P. Barrett, L. J. Morrison

This study compares metabolism between Trypanosoma congolense and T. brucei, finding differences in glucose uptake, glycolytic endpoints, and drug sensitivity.

bioRxiv · Jan 5, 2021Microbiology

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

bioRxiv · Apr 24, 2019Microbiology