W. Wei

MDF regulates a network of auxin-dependent and -independent pathways of adventitious root regeneration in Arabidopsis.

The paper identifies MDF as a regulator that coordinates auxin-dependent and -independent pathways in adventitious root regeneration in Arabidopsis.

A receptor kinase complex refines cambium activity in Arabidopsis

This study identifies PXY-ER complexes as essential for cambium activity in Arabidopsis, showing that PXY signaling depends on ER signaling and explains ER function in the cambium.

Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in Sorghum and Sugarcane

This paper shows that increasing Rubisco content in sorghum and sugarcane through genetic modification improves photosynthetic efficiency and productivity, with field and greenhouse trials showing biomass increases of 15.5% and 37-81% respectively.

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance

The paper identifies functional mutations affecting PD-L1 and HLA-I expression using a large-scale CRISPR screen, revealing clinically relevant variants that influence immunotherapy response.

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

Simultaneous generation of osteoblasts and adipocytes by a bivalent differentiation medium from bone marrow stromal/stem cells (BMSCs)

This paper introduces a bivalent differentiation medium that enables BMSCs to simultaneously generate osteoblasts and adipocytes, with a method to assess lineage commitment using staining techniques.

Neutrophil Extracellular Traps Drive a skin-kidney inflammatory axis in UVB-Irradiated Lupus-Prone Mice

This study identifies a skin-kidney inflammatory axis driven by UVB-induced NETosis in lupus-prone mice, highlighting PKC and CXCR4 as therapeutic targets.

CEP44 is required for maintaining centriole duplication and spindle integrity

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

This study uses genome editing in adult mice with a MIR96 mutation to restore hearing, showing efficacy that improves with earlier intervention.

POLARIS is a copper-binding peptide required for ethylene signalling control in Arabidopsis.

The paper identifies PLS as a copper-binding peptide that modulates ethylene signaling in Arabidopsis by interacting with ETR1 and regulating copper-dependent repression of ethylene responses.

Internalized beta2-Adrenergic Receptors Inhibit Subcellular Phospholipase C-Dependent Cardiac Hypertrophic Signaling

The paper shows that internalized beta2-Adrenergic Receptors inhibit PLCε signaling at the Golgi, reducing cardiac hypertrophy by blocking PKD and HDAC5 phosphorylation.

A class of secreted mammalian peptides with potential to expand cell-cell communication

The paper identifies a new class of secreted mammalian peptides, capped peptides, which may regulate cell-cell communication through post-translational modifications.

Evolutionary Insights from a Large-scale Survey of Population-genomic Variation

This study analyzes population-genomic variation in Daphnia pulex to reveal evolutionary-genomic features and identify genes under selection.

The Genome-wide Signature of Short-term Temporal Selection

This study analyzes genome-wide selection patterns in Daphnia pulex over nine years, finding fluctuating selection with near-zero mean coefficients and weak negative selection on minor alleles.

Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptide

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

Stablization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

Spatiotemporal cell landscape of human embryonic tooth development

The paper maps the spatiotemporal cell landscape of human embryonic tooth development using single-cell RNA sequencing and spatial transcriptomics, identifying key cell types and regulatory networks.

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

Exosome-mediated viral nucleic acid presentation in a crustacean reveals innate immunity evolution from a novel perspective

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

High growing season temperatures limit winter recovery of grapevines from Xylella fastidiosa infection: implications for epidemiology in hot climates

This study shows that high summer temperatures limit winter recovery of grapevines infected with Xylella fastidiosa, reducing the potential for disease recovery in warm climates.

Nascent-Chain Interaction Networks and Their Effect on the Bacterial Ribosome

This study identifies specific ribosomal protein interactions with nascent chains of foldable proteins and shows the ribosome provides unbiased support to RNCs regardless of sequence or foldability.

Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis)

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

3D in vitro blood-brain-barrier model for investigating barrier insults

This paper presents a 3D human BBB model with real-time monitoring of barrier tightness and shows that oxygen-glucose deprivation causes rapid actin remodeling and barrier disruption.

Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

This study identifies genes conferring resistance to SHP2 inhibitors through CRISPR screens and shows their roles in reactivating ERK signaling in cancer cells.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.