Cell BiologybioRxiv
Lamin B Receptor Upregulation in Metastatic Melanoma Causes Cholesterol-Mediated Nuclear Envelope Fragility
M. A. Baird, R. S. Fischer, C. E. Jewett…·C. M. Waterman
This study shows that increased LBR cholesterol synthase activity in metastatic melanoma leads to nuclear envelope fragility by accumulating cholesterol, promoting NE rupture during cell migration.
DOI 10.1073/pnas.2513031123