R. Vince

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice

This study shows that deleting Glyoxalase 1 worsens acetaminophen-induced liver damage in mice by increasing oxidative stress and necrosis.