Author

R. Wubbolts

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. de Bruin· 1 shared B. Westendorp· 1 shared E. Moreno· 1 shared F. M. Riemers· 1 shared H. S. Segeren· 1 shared L. M. van Rijnberk· 1 shared R. Yuan· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. de Bruin

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1 paper

Recent·Most cited

Cancer BiologybioRxivMar 19, 2020

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage.

H. S. Segeren, L. M. van Rijnberk, E. Moreno…·B. Westendorp

The paper shows that high E2F transcription in cancer cells prevents cell cycle exit after DNA damage, leading to genomic instability and reduced drug sensitivity.

DOI 10.1016/j.celrep.2020.108449

humanbulk RNA-seq

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