Author

R.-A. Garibsingh

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Schlessinger· 1 shared C. Grewer· 1 shared G. Eisenberg· 1 shared J. Wang· 1 shared K. Hutchinson· 1 shared X. Yu· 1 shared Y. Dong· 1 shared Y. Shi· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

A. Schlessinger

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1 paper

Recent·Most cited

Conserved allosteric inhibition mechanism in SLC1 transporters

Y. Dong, J. Wang, R.-A. Garibsingh, K. Hutchinson, Y. Shi, G. Eisenberg, X. Yu, A. Schlessinger, C. Grewer

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

bioRxiv · Sep 21, 2022Biophysics