Cancer BiologybioRxivPreprint
Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5
Martin Benej, Katarina Benejova, Adel Fergatova…·Nicholas C. Denko
This study shows that NDUFB5 amplification in NSCLC drives tumor hypoxia and therapy resistance by increasing mitochondrial oxygen consumption.
DOI 10.64898/2026.07.27.741033