Cell BiologybioRxivPreprint
Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation
Ning Zhang, Abdul Samad, Farnaz Zahedifard…·Mark C. Field
This study identifies CPSF3 as a target of benzoxaboroles in trypanosomatids, showing that BoBs induce sumoylation-dependent degradation of CPSF complex members, leading to reduced mRNA levels.