Cell BiologybioRxiv
CtBP restricts DUX-dependent and -independent genetic program for the 2-cell-like state in murine embryonic stem cells
K. Yoshioka, K. Sugiyama, M. Ichisakino…·Y. Seki
The paper shows that Ctbp1/2 disruption activates DUX-dependent and -independent pathways in mESCs, leading to 2-cell-like state features through PRAMEL7 upregulation.
DOI 10.1038/s44319-026-00881-7