S. A. Leachman

The paper shows that T cell egress via lymphatic vessels limits intratumoral T cell diversity, and that CXCR4 inhibition enhances T cell retention and improves immunotherapy response.

This paper uses quantitative multiplex immunohistochemistry to analyze lymphovascular and immune heterogeneity in primary cutaneous melanoma, finding that vessel subtypes correlate with immune infiltration and metastatic risk.