K. White

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

Heterologous Prime-Boost with Immunologically Orthogonal Protein Nanoparticles for Peptide Immunofocusing

This paper develops a vaccine strategy using immunologically orthogonal protein nanoparticles to focus antibody responses on a specific SARS-CoV-2 RBD epitope.

Programmed withdrawal of cilia maintenance followed by centriole capping leads to permanent cilia loss during cerebellar granule cell neurogenesis

The paper identifies a programmed cilia deconstruction pathway in cerebellar granule cells during neurogenesis, showing decreased cilia maintenance and centriole capping prevent cilia regrowth and dysregulated signaling.

Permanent deconstruction of intracellular primary cilia in differentiating granule cell neurons

The paper investigates ciliary dynamics in differentiating granule cell neurons, finding that cilia are deconstructed intracellularly and do not reform in adult neurons.

Characterization of Ralstonia pseudosolanacearum diversity and screening host resistance to manage bacterial wilt in South Asia

The paper surveys RSSC pathogens in Bangladesh and Nepal, characterizes their genetic diversity, and screens crop accessions for resistance to bacterial wilt.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

Quantitative multiplex immunohistochemistry reveals inter- and intra-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

This paper uses quantitative multiplex immunohistochemistry to analyze lymphovascular and immune heterogeneity in primary cutaneous melanoma, finding that vessel subtypes correlate with immune infiltration and metastatic risk.

Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture

This paper evaluates HCV protease inhibitors as potential SARS-CoV-2 antivirals, finding that simeprevir and grazoprevir synergize with remdesivir to enhance antiviral activity against SARS-CoV-2 in cell culture.

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

This study shows oxidative stress causes structural changes in cardiac myocyte microtubules, leading to a static, acetylated network that contributes to heart failure.

Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles

The paper uses single-cell RNA sequencing to identify new targets for isolating skeletal stem cells from human bone marrow using DNA-coated gold nanoparticles.

Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis, and Poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets

This study analyzes transcriptomic data from SIV-infected macaques to identify altered metabolic pathways and PARPs as potential therapeutic targets in HIV-associated neurodegeneration.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Enhancing Myocardial Repair with CardioClusters

This paper introduces CardioClusters, 3D microenvironments of cardiac interstitial cells that enhance myocardial repair by improving cell retention, function, and structural outcomes in a murine infarction model.

Citizen science and aquatic macroinvertebrates: public engagement for catchment-scale pollution vigilance

The paper evaluates a citizen science program for monitoring aquatic macroinvertebrates to assess its role in pollution detection and public engagement in river management.

Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends in cells

The paper shows that EB1 tracks microtubule ends by recognizing structural changes, not just GTP-tubulin binding, using simulations and experiments.

A Guide To Analysis And Reconstruction Of Serial Block Face Scanning Electron Microscopy Data

This paper provides a step-by-step protocol for analyzing and reconstructing SBF-SEM data using Fiji, Amira, and MIB, highlighting the suitability of different tools for various structures.