Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath Tumors
S. Farouk Sait, K.-h. Tang, S. Angus, R. Brown, D. Sun, X. Xie, C. Iltis, M. Lien, N. Socci, T. Bale, C. Davis, S. A. H. Dixon, C. Zhang, D. W. Clapp, B. G. Neel, L. F. Parada
This study shows that combining SHP2 and autophagy inhibition effectively suppresses NF1-associated MPNSTs in mouse models, suggesting a potential new treatment approach.
bioRxiv · Aug 18, 2022 · PreprintCancer Biology