Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling
A. A. Chomiak, R. Tiedemann, Y. Liu, X. Kong, Y. Cui, K. Thurlow, E. M. Cornett, M. J. Topper, S. Baylin, S. B. Rothbart
The paper shows that combining DNMT inhibitors with selective EZH2 inhibitors enhances antiproliferative effects in colon cancer by modulating calcium-calcineurin-NFAT signaling and viral mimicry.
bioRxiv · Jun 9, 2023Cancer Biology